With anti-EU sentiment growing across the continent, is Italy the next nation to leave?

The rise of anti-establishment, populist, parties after the weekends election in Italy will have ‘signifiant meaning for the EU,’ one minister has warned.

Both the anti-establishment Five Star Movement (M5S) and right-wing Lega party seeing strong gains in the vote Sunday.

Meanwhile, parties like Silvio Berlusconi’s Forza Italia and the ruling Democratic Party (PD) fell short of expectations, prompting PD leader and former Prime Minister Matteo Renzi to resign.

Italy’s former Foreign Minister Giulio Terzi di Sant’Agata told CNBC Monday that the vote had “significant meaning” for Italy’s relationship with its neighbors.

 “It’s been a clear indication that the majority of Italian voters want a change. They want a change that is significant in relation to a number of issues which are considered a high-priority now by at least 60 percent, and perhaps more, of Italian voters.”